“Prominent research is reviewed which shows that advanced drug delivery of curcumin (curcumin nanoformulations or curcumin nanomedicine) is able to leverage therapeutic benefits by improving bioavailability and pharmacokinetics which in turn improves binding, internalization and targeting of tumor(s).”
Curcumin Nanomedicine: A Road to Cancer Therapeutics,
Murali M. Yallapu, et al., Curr Pharm Des. 2013
“Overall, our findings suggested that Cur(cumin) micelles could be a stabilized aqueous formulation for intravenous application with improved antitumor activity, which may be a potential treatment strategy for colon cancer in the future.”
Curcumin-Encapsulated Polymeric Micelles Suppress the Development of Colon Cancer In Vitro and In Vivo, Xi Yang, et al., Scientific Reports, Nature, 2015
“Evidence from numerous literatures revealed that curcumin has poor absorption, biodistribution, metabolism, and bioavailability. Thus, continuous research on curcumin found some possible ways to overcome these problems. To increase the bioavailability, longer circulation, better permeability, and resistance to metabolic processes of curcumin, several formulations have been prepared which include nanoparticles, liposomes, micelles, and phospholipid complexes.”
Recent Developments in Delivery, Bioavailability, Absorption and
Metabolism of Curcumin: the Golden Pigment from Golden Spice,
Prasad S,.. Aggarwal, B, MD Anderson Cancer Center, 2014
“Another study also showed that piperine when administered with curcumin enhances the bioavailability of the latter up to 20-fold more in epileptic rats.”
Recent Developments in Delivery, Bioavailability, Absorption and
Metabolism of Curcumin: the Golden Pigment from Golden Spice, Recent Developments in Delivery, Bioavailability, Absorption and
Metabolism of Curcumin: the Golden Pigment from Golden Spice
Sahdeo Prasad, PhD, Amit K. Tyagi, PhD, Bharat B. Aggarwal, PhD,
Cancer Res Treat. 2014
The last decade has witnessed rapid advancement in the development of nanochemopreventive technology with emergence of many nano encapsulated formulations of different dietary anticancer agents.
Progress in Nanotechnology Based Approaches to Enhance the Potential of Chemopreventive Agents, Irfana Muqbi, et al., 2011
Bioavailability Multiplied
New, commercially-available formulations of nutritional agents have increased bioavailability (potency, effectiveness) of these agents by factors of 10-50X. This means that smaller doses can deliver more healing capacity in a shorter period. Greater volumes of the agent reach the targeted tissue. It is rarely reported that the healing mechanisms of nutritional agents are “dose dependent,” meaning that the more of the agent to reach the targeted, diseased tissue, the greater the power it has to heal the disease.
Specifically Targeting the Disease Microenvironment
Chronic diseases at the cell level exhibit the common trait of altered metabolism. This metabolism both consumes nutritients and secretes them. The secreted nutrients are primarily lactate. This mechanism, in turn, creates a unique extra-cellular environment. This unique environment is acidic and experiences continuous turnover or the structure and compounds that make up its structure, the extra-cellular matrix. The environment created, the microenvironment, is precisely configured to capture and take up nutritional metabolites. Thus, nutritional agents, when configured and delivered properly, will specifically target diseased tissue at the cell level, the disease microenvironment.